Triple F - A Comet Nucleus Sample Return Mission

The Triple F (Fresh From the Fridge) mission, a Comet Nucleus Sample Return, has been proposed to ESA s Cosmic Vision program. A sample return from a comet enables us to reach the ultimate goal of cometary research. Since comets are the least processed bodies in the solar system, the proposal goes far beyond cometary science topics (like the explanation of cometary activity) and delivers invaluable information about the formation of the solar system and the interstellar molecular cloud from which it formed. The proposed mission would extract three samples of the upper 50 cm from three locations on a cometary nucleus and return them cooled to Earth for analysis in the laboratory. The simple mission concept with a touch-and-go sampling by a single spacecraft was proposed as an M-class mission in collaboration with the Russian space agency ROSCOSMOS

Data-Driven Regionalization of Decarbonized Energy Systems for Reflecting Their Changing Topologies in Planning and Optimization

The decarbonization of energy systems has led to a fundamental change in their topologysince generation is shifted to locations with favorable renewable conditions. In planning, this changeis reflected by applying optimization models to regions within a country to optimize the distributionof generation units and to evaluate the resulting impact on the grid topology. This paper proposesa globally applicable framework to find a suitable regionalization for energy system models witha data-driven approach. Based on a global, spatially resolved database of demand, generation,and renewable profiles, hierarchical clustering with fine-tuning is performed. This regionalizationapproach is applied by modeling the resulting regions in an optimization model including asynthesized grid. In an exemplary case study, South Africa’s energy system is examined. The resultsshow that the data-driven regionalization is beneficial compared to the common approach of usingpolitical regions. Furthermore, the results of a modeled 80% decarbonization until 2045 demonstratethat the integration of renewable energy sources fundamentally changes the role of regions withinSouth Africa’s energy system. Thereby, the electricity exchange between regions is also impacted,leading to a different grid topology. Using clustered regions improves the understanding and analysisof regional transformations in the decarbonization process

The Hera Radio Science Experiment at Didymos

Hera represents the European Space Agency's inaugural planetary defence space mission, and plays a pivotal role in the Asteroid Impact and Deflection Assessment international collaboration with NASA DART mission that performed the first asteroid deflection experiment using the kinetic impactor techniques. With the primary objective of conducting a detailed post-impact survey of the Didymos binary asteroid following the DART impact on its small moon called Dimorphos, Hera aims to comprehensively assess and characterize the feasibility of the kinetic impactor technique in asteroid deflection while conducting in-depth investigation of the asteroid binary, including its physical and compositional properties as well as the effect of the impact on the surface and/or shape of Dimorphos. In this work we describe the Hera radio science experiment, which will allow us to precisely estimate key parameters, including the mass, which is required to determine the momentum enhancement resulting from the DART impact, mass distribution, rotational states, relative orbits, and dynamics of the asteroids Didymos and Dimorphos. Through a multi-arc covariance analysis we present the achievable accuracy for these parameters, which consider the full expected asteroid phase and are based on ground radiometric, Hera optical images, and Hera to CubeSats InterSatellite Link radiometric measurements. The expected formal uncertainties for Didymos and Dimorphos GM are better than 0.01% and 0.1%, respectively, while their J2 formal uncertainties are better than 0.1% and 10%, respectively. Regarding their rotational state, the absolute spin pole orientations of the bodies can be recovered to better than 1 degree, and Dimorphos spin rate to better than 10^-3%. Dimorphos reconstructed relative orbit can be estimated at the sub-m level [...

Assessing the biological reactivity of organic compounds on volcanic ash: implications for human health hazard

Exposure to volcanic ash is a long-standing health concern for people living near active volcanoes and in distal urban areas. During transport and deposition, ash is subjected to various physicochemical processes that may change its surface composition and, consequently, bioreactivity. One such process is the interaction with anthropogenic pollutants; however, the potential for adsorbed, deleterious organic compounds to directly impact human health is unknown. We use an in vitro bioanalytical approach to screen for the presence of organic compounds of toxicological concern on ash surfaces and assess their biological potency. These compounds include polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dlPCBs). Analysis of ash collected in or near urbanised areas at five active volcanoes across the world (Etna, Italy; Fuego, Guatemala; Kelud, Indonesia; Sakurajima, Japan; Tungurahua, Ecuador) using the bioassay inferred the presence of such compounds on all samples. A relatively low response to PCDD/Fs and the absence of a dlPCBs response in the bioassay suggest that the measured activity is dominated by PAHs and PAH-like compounds. This study is the first to demonstrate a biological potency of organic pollutants associated with volcanic ash particles. According to our estimations, they are present in quantities below recommended exposure limits and likely pose a low direct concern for human health

ASIME 2018 White Paper. In-Space Utilisation of Asteroids: Asteroid Composition -- Answers to Questions from the Asteroid Miners

In keeping with the Luxembourg government's initiative to support the future use of space resources, ASIME 2018 was held in Belval, Luxembourg on April 16-17, 2018. The goal of ASIME 2018: Asteroid Intersections with Mine Engineering, was to focus on asteroid composition for advancing the asteroid in-space resource utilisation domain. What do we know about asteroid composition from remote-sensing observations? What are the potential caveats in the interpretation of Earth-based spectral observations? What are the next steps to improve our knowledge on asteroid composition by means of ground-based and space-based observations and asteroid rendez-vous and sample return missions? How can asteroid mining companies use this knowledge? ASIME 2018 was a two-day workshop of almost 70 scientists and engineers in the context of the engineering needs of space missions with in-space asteroid utilisation. The 21 Questions from the asteroid mining companies were sorted into the four asteroid science themes: 1) Potential Targets, 2) Asteroid-Meteorite Links, 3) In-Situ Measurements and 4) Laboratory Measurements. The Answers to those Questions were provided by the scientists with their conference presentations and collected by A. Graps or edited directly into an open-access collaborative Google document or inserted by A. Graps using additional reference materials. During the ASIME 2018, first day and second day Wrap-Ups, the answers to the questions were discussed further. New readers to the asteroid mining topic may find the Conversation boxes and the Mission Design discussions especially interesting.Comment: Outcome from the ASIME 2018: Asteroid Intersections with Mine Engineering, Luxembourg. April 16-17, 2018. 65 Pages. arXiv admin note: substantial text overlap with arXiv:1612.0070

Rosetta Zoo: finding changes on comet 67P

Comets are generally considered to be relatively pristine objects, having spent most of their existence at large heliocentric distances where there is not enough energy to significantly transform these objects. Comets, therefore, offer a window into the early Solar System; their physical and chemical properties reflect the conditions in their formation environment [1]. Yet, most comets that have been visited by spacecraft are small-period comets that circle the Sun in 10 years or less, meaning that their surface is no longer as pristine as we would need to investigate their origins, having been modified by several processes such as impacts, sublimation, dust deposition and explosive outbursts over many orbits around the Sun. To learn about the early Solar System, we need to understand these evolution processes and recover the original conditions, and this requires building an exhaustive catalog of all types of changes that may have taken place, as well as the timeline of this evolution. ESA's Rosetta mission at comet 67P provides the perfect data set for such a task [2]. Having monitored the comet's surface for two years, across perihelion, Rosetta witnessed a handful of large-scale changes such as cliff retreat, the deflation of smooth terrains and the transport of large size blocks. A whole lot more took place on smaller scales: a careful examination of selected high-resolution images has shown thousands of changes on a 1-10 meter scale, including the formation of small pits, impacts, rolling and bouncing boulders. The most significant changes have been presented in several publications [3-9], as well as the connection between morphological evolution and activity [10,11]. However, more than 5 years after the end of the mission, we still lack a complete description of changes at all scales. This is a challenging task, because most transformations are small (meter-size or less), which means the associated surface features occupy only a few pixels in the high-resolution images returned by Rosetta (OSIRIS NAC [12]).Over the last years, we have started to systematically analyze images from different epochs, and developed specialized algorithms to assist in the detection of surface changes [13]. The results are promising, but only a subset of the data was analyzed, as the algorithm requires images to be co-aligned, a much time consuming step. In order to speed up the process and analyze the full surface, we have enlisted the help of thousands of comet enthusiasts through a citizen science project steered by ESA and Zooniverse. Volunteers are viewing pairs of OSIRIS images of the same region of the comet, taken before and after the perihelion passage, and we ask them to identify whether they see significant modifications between the two images, marking the areas that display changes in the two images with purposely-designed tools. Volunteers are also asked to label the type of change in the images.This will produce maps of changes and active areas on the comet's surface, with labels for each type of change, from the visual inspection of many volunteers, enabling us to associate activity with surface modifications and thus develop new models linking the physics of comet activity to observed changes like lifted boulders and collapsed cliffs.The database created from this citizen science project will also be used to verify the results given by the change detection algorithm, and will provide an excellent training set for potentially new machine learning efforts.The project launched on the 5th of May 2022 and several thousands of classifications have already been performed by the first volunteers. We will monitor this collaborative work over the coming months and report on the first results at EPSC in September 2022

Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer

Purpose: Zoledronic acid (ZA) or denosumab treatment reduces skeletal-related events; however, the safety of prolonged therapy has not been adequately studied. Here, we describe safety results of extended denosumab therapy in patients with bone metastases from the open-label extension phase of two phase 3 trials. Methods: Patients with metastatic breast or prostate cancer received subcutaneous denosumab 120 mg Q4W or intravenous ZA 4 mg Q4W in a double-blinded fashion. Denosumab demonstrated superior efficacy in the blinded treatment phase; thus, patients were offered open-label denosumab for up to an additional 2 years. Results: Cumulative median (Q1, Q3) denosumab exposure was 19.1 (9.2, 32.2) months in the breast cancer trial (n = 1019) and 12.0 (5.6, 21.3) months in the prostate cancer trial (n = 942); 295 patients received denosumab for >3 years. No new safety signals were identified during the open-label phase, or among patients who switched from ZA to denosumab. During the blinded treatment phase, exposure-adjusted subject incidences of osteonecrosis of the jaw (ONJ) were 49 (1.9 %) and 31 (1.2 %) in the denosumab and ZA groups, respectively. In total, 32 (6.9 %) and 25 (5.5 %) new cases of ONJ (not adjusted for exposure) were reported for patients continuing and switching to denosumab, respectively. The incidences of hypocalcemia were 4.3 and 3.1 %, in patients continuing and switching to denosumab, respectively. Conclusion: These results describe the safety profile of denosumab after long-term exposure, or after switching to denosumab from ZA. No new safety signals were identified. Hypocalcemia rates were similar in the blinded treatment and open-label phases. ONJ rates increased with increasing exposure to antiresorptives, consistent with previous reports

Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks

The impact of the DART spacecraft into Dimorphos, moon of the asteroid Didymos, changed Dimorphos' orbit substantially, largely from the ejection of material. We present results from twelve Earth-based facilities involved in a world-wide campaign to monitor the brightness and morphology of the ejecta in the first 35 days after impact. After an initial brightening of ~1.4 magnitudes, we find consistent dimming rates of 0.11-0.12 magnitudes/day in the first week, and 0.08-0.09 magnitudes/day over the entire study period. The system returned to its pre-impact brightness 24.3-25.3 days after impact through the primary ejecta tail remained. The dimming paused briefly eight days after impact, near in time to the appearance of the second tail. This was likely due to a secondary release of material after re-impact of a boulder released in the initial impact, through movement of the primary ejecta through the aperture likely played a role.Comment: 16 pages, 5 Figures, accepted in the Astrophysical Journal Letters (ApJL) on October 16, 202